Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

CM Vachon; CG Scott; RM Tamimi; DJ Thompson; PA Fasching; J Stone; MC Southey; S Winham; S Lindström; J Lilyquist; GG Giles; RL Milne; RJ MacInnis; L Baglietto; J Li; K Czene; MK Bolla; Q Wang; J Dennis; L Haeberle; M Eriksson; P Kraft; R Luben; N Wareham; JE Olson; A Norman; EC Polley; G Maskarinec; L Le Marchand; CA Haiman; JL Hopper; FJ Couch; DF Easton; P Hall; N Chatterjee; M Garcia-Closas

Journal article

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

CM Vachon, CG Scott, RM Tamimi, DJ Thompson, PA Fasching, J Stone, MC Southey, S Winham, S Lindström, J Lilyquist, GG Giles, RL Milne, RJ MacInnis, L Baglietto, J Li, K Czene, MK Bolla, Q Wang, J Dennis, L Haeberle Show all

Breast Cancer Research | BMC | Published : 2019

DOI: 10.1186/s13058-019-1138-8

Download PDF

Abstract

Background: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important to more accurately predict risk. Methods: Using 3628 breast cancer cases and 5126 controls of European ancestry from eight case-control studies, we evaluated joint associations of a 77-single nucleotide polymorphism (SNP) PRS and quantitative mammographic density measures with breast cancer. Mammographic percent density and absolute dense area were evaluated using thresholding software and examine..

View full abstract

University of Melbourne Researchers

Jennifer Stone Author

Melissa Southey Author

Graham Giles Author

Roger Milne Author

Related Projects (2)

Epidemiology of chronic disease, health interventions and DNA studies

THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

Grants

Awarded by Breast Cancer Research Foundation

Funding Acknowledgements

This work was supported by the National Cancer Institute (R01 CA128931, R01 CA122340, R01 CA128978, R01 CA97396, P50 CA116201, R01 CA240386, K24 CA169004, R21 CA179442, P01 CA154292, P01CA87969, R01 CA085265, UM1CA176726, UM1CA186107, and U01 CA164973) and the Breast Cancer Research Foundation. BBCC was supported in part by the ELAN program of the Medical Faculty, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg. Funding for the genotyping of BBCC and MCBCS as well as the iCOGS Illumina array is provided by grants from the EU FP7 programme (COGS) and from Cancer Research UK. Collaborative Oncological Gene-environment Study (COGS) enabled the genotyping for this study. Funding for the BCAC component is provided by grants from the EU FP7 programme (COGS) and from Cancer Research UK. BCAC is funded by Cancer Research UK [C1287/A16563] and by the European Community's Seventh Framework Programme under grant agreement no 223175 (HEALTH-F2-2009-223175) (COGS) and by the European Union's Horizon 2020 Research and Innovation Programme under grant agreements 633784 (B-CAST) and 634935 (BRIDGES). The SASBAC study was supported by the Marit and Hans Rausing's Initiative Against Breast Cancer, the National Institutes of Health (RO1 CA58427), the Agency for Science, Technology and Research (A*STAR; Singapore), and the Swedish Research Council. Jingmei Li is a recipient of a National Research Foundation Singapore Fellowship (NRF-NRFF2017-02). The Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council grants 209057 and 396414 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database.